Common NameHydroxylamine
DescriptionHydroxylamine is a reactive chemical with formula NH2OH. It can be considered a hybrid of ammonia and water due to parallels it shares with each. At room temperature pure NH2OH is ordinarily a white, unstable crystalline, hygroscopic compound; however it is almost always encountered as an aqueous solution. A colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide. Hydroxylamine may explode on heating. It is an irritant to the respiratory tract, skin, eyes, and other mucous membranes. It may be absorbed through the skin, is harmful if swallowed, and is a possible mutagen. NH2OH is an intermediate in the biological nitrification. The oxidation of NH3 is mediated by HAO (hydroxylamine oxidoreductase).
Structure
Molecular FormulaH3NO
Average Mass33.02990
Monoisotopic Mass33.02146
IUPAC Namehydroxylamine
Traditional NameHydroxylamine
CAS Registry Number7803-49-8
SMILESNO
InChI IdentifierInChI=1S/H3NO/c1-2/h2H,1H2
InChI KeyAVXURJPOCDRRFD-UHFFFAOYSA-N
CHEBI IDCHEBI:15429
HMDB IDHMDB0003338
StateNot Available
Water SolubilityNot Available
logP-0.74
logSNot Available
pKa (Strongest Acidic)17.65
pKa (Strongest Basic)3.94
Hydrogen Acceptor Count2
Hydrogen Donor Count2
Polar Surface Area46.25 Ų
Rotatable Bond Count0
Physiological Charge0
Formal Charge0
Refractivity7.85 m³·mol⁻¹
Polarizability2.78

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