| Description | 5-Aminopentanal belongs to the class of organic compounds known as alpha-hydrogen aldehydes. These are aldehydes with the general formula HC(H)(R)C(=O)H, where R is an organyl group. 5-Aminopentanal is a very strong basic compound (based on its pKa). 5-Aminopentanal exists in all living organisms, ranging from bacteria to humans. Thus, a double scenario arises, showing the use of aldehydes from diamines to obtain a large number of organisms of Leishmania infantum promastigotes to use in serological studies, whereas the aldehydes derived from polyamines could be used as a new strategy for therapeutic treatment against these parasites. The aminoaldehydes 5-aminopentanal, derived from the oxidation of the diamines putrescine and cadaverine,is produced utilizing a copper amine oxidase (CAO) from Euphorbia characias latex and tested with in vitro cultivation of Leishmania infantum promastigotes. Outside of the human body, 5-Aminopentanal has been detected, but not quantified in, several different foods, such as malabar plums, bamboo shoots, custard apples, common salsifies, and grapes. This could make 5-aminopentanal a potential biomarker for the consumption of these foods. Whereas the aminoaldehydes derived from the oxidation of the diamines were stimulating factors for growth of Leishmania infantum promastigotes, the aldehydes derived from polyamines oxidation had a drastic inhibitory effect on the vitality and growth of these parasites. 5-Aminopentanal is expected to be in Cannabis as all living plants are known to produce and metabolize it. |
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